Early Epidemics in South Carolina
| 1671 | A "sickness" | 1709 | Influenza, Malaria |
| 1684 | Malaria | 1711 | Influenza, Smallpox,
Malaria, Yellow Fever |
| 1697-98 | Smallpox | 1715 | Dysentery |
| 1699 | Yellow Fever | 1717 | Influenza |
| 1700 | Yellow Fever | 1718 | Smallpox, Yellow Fever |
| 1706 | Yellow Fever | 1724 | Quinzey |
| 1728 | Yellow Fever, Pleurisy | 1746 | Yellow Fever |
| 1732 | Smallpox, Yellow Fever | 1747 | Measles |
| 1733 | Measles, Yellow Fever | 1748 | Yellow Fever |
| 1738 | Smallpox, Whooping Cough | 1749 | Whooping Cough, Yellow Fever, Pleurisy |
| 1739 | Yellow Fever | 1750 | Yellow Fever |
| 1740 | Smallpox | 1751 | Quinzies, Diphtheria, Flux |
| 1743 | Quinzey | 1752 | Flux |
| 1745 | Yellow Fever, Mumps | 1753 | Yellow Fever |
| 1755 | Yellow Fever, Whooping Cough | 1770 | Quinzey |
| 1758 | Smallpox, Yellow Fever | 1772 | Measles |
| 1759 | Yellow Fever, Whooping Cough, Measles | 1775 | Measles |
| 1760 | Smallpox | 1781 | Typhus, Smallpox |
| 1761 | Typhus, Yellow Fever | 1787 | Scarlatina Anginosa |
| 1763 | Smallpox | 1788 | Scarlatina Anginosa |
| 1765 | Whooping Cough | 1790 | Influenza |
| 1768 | Mumps | 1792 | Yellow Fever |
| 1794 | Yellow Fever | 1809 | Yellow Fever, Whooping Cough |
| 1795 | Yellow Fever | 1814 | Diphtheria |
| 1796 | Yellow Fever | 1815 | Influenza |
| 1797 | Yellow Fever | 1816 | Influenza, Smallpox |
| 1799 | Yellow Fever | 1817 | Yellow Fever |
| 1800 | Yellow Fever | 1819 | Yellow Fever |
| 1807 | Influenza | 1824 | Yellow Fever |
Resource:
Colleton County, South Carolina, A History of the First 160 Years,
1670-1830,
by Evelyn McDaniel Frazier Bryan, pub. 1969, 1974